Tromethamine

Tromethamine, commonly known as TRIS, is a versatile organic compound widely used in the pharmaceutical, cosmetic, and industrial sectors. It serves as a buffering agent, stabilizer, and a key ingredient in various formulations, bridging the gap between specialized applications and consumer products.

Chemicals Characteristics

Synonyms: TRIS, Tris(hydroxymethyl)aminomethane, THAM
Chemical Formula: C₄H₁₁NO₃
CAS Number: 77-86-1

Molar Weight

121.14 g/mol

Melting Point

167-172 °C

Boiling Point

219 °C

Flash Point

207 °C

Density

1.186 g/cm³

Forms

Crystalline powder, Colorless

Key Points/Overview

Tromethamine (TRIS) is a multi-functional compound, essential in both specialized and general applications. It is commonly used as a buffering agent in biological research and in the formulation of cosmetics and pharmaceuticals. Its versatility makes it a valuable asset in various industrial processes, including water treatment and textile manufacturing.

It’s important to note that occupational exposure to glacial acetic acid can happen via inhalation or contact with skin and eyes. Regulatory bodies like OSHA have established guidelines to manage and limit such exposure.

Uses & Benefits

Pharmaceutical Applications:
Tromethamine is a cornerstone in the pharmaceutical industry, particularly in the formulation of intravenous medications. For pharmaceutical companies aiming for excellence, TRIS offers unparalleled buffering capabilities.
Cosmetic Formulations:
In the beauty and personal care sector, TRIS is not just an ingredient; it’s a game-changer. Used in lotions, creams, and serums, it enhances product stability and user experience, making it indispensable for premium cosmetic brands.
Industrial Buffering:
TRIS is the go-to solution for industrial buffering needs. From wastewater treatment to textile manufacturing, its buffering efficiency is unmatched, making it a must-have for industries requiring pH control.

Safety Information

Consumer Exposure:
TRIS is commonly found in a variety of consumer products, including cosmetics and personal care items. While generally safe for topical application, consumers should always read labels for concentration levels to ensure safe usage.
Occupational Exposure:
In industrial settings, exposure to TRIS can occur through skin contact or inhalation. Strict adherence to safety guidelines, including the use of Personal Protective Equipment (PPE), is crucial for maintaining workplace safety.