PVP K17, K30 & K90 (Pharma Grade)

Acetic anhydride is a highly effective organic reagent appreciated for its exceptional acetylation capabilities, which makes it integral to numerous industrial applications including pharmaceuticals and textiles.

This clear, colorless liquid is particularly renowned for synthesizing acetylated compounds such as aspirin, playing a pivotal role in the pharmaceutical industry. Industries rely on it due to its consistent reactivity, ease of handling, and ability to enhance product performance through targeted acetylation.

Chemicals Characteristics

Synonyms: Povidone, Polyvidone
Chemical Formula: (C₆H₉NO)ₙ
CAS Number: 9003-39-8

Molar Weight

2,500–2,500,000 g/mol (variable depending on the polymer chain length)

Melting Point

Not well-defined (high thermal stability)

Boiling Point

Not typically applicable for polymers

Flash Point

Not applicable for polymers

Density

Approximately 1.2 g/cm³ (bulk density can vary)

Forms

White to yellowish-white powders or flakes

Entire form

Key Points/Overview

PVP is valued for its excellent binding, emulsifying, and filming abilities, which make it suitable for pharmaceutical and cosmetic applications. It is chemically stable and non-ionic, allowing it to function effectively across a broad pH range and with diverse active pharmaceutical ingredients.

Its strong adhesive and cohesive properties support its use as a binder in tablet formulation, while its film-forming nature enables it to act as a protective coating agent. In addition, PVP enhances the solubility and dispersibility of compounds, improving the performance and bioavailability of many drug formulations. In cosmetics, its use in hair sprays, gels, and skincare products offers flexibility, texture enhancement, and product stability.

Uses & Benefits

PVP demonstrates exceptional adaptability across various sectors, serving critical roles in formulations that require stability, solubility, and consistency. Its ability to function under diverse formulation conditions has made it an indispensable ingredient in many pharmaceutical and consumer care products.

Pharmaceutical Industry

PVP is widely used in the pharmaceutical sector for its excipient properties:

  • Binder: Provides mechanical strength to tablets and aids in granule formation during wet granulation.

  • Solubility Enhancer: Improves the dissolution rate and bioavailability of poorly soluble active ingredients.

  • Film Former: Used for coating solid dosage forms to protect active ingredients and mask taste.

Cosmetic and Personal Care

Its application in personal care products is driven by its film-forming and emulsifying properties:

  • Hair Care Products: Used in sprays, gels, and shampoos for hold and flexibility without residue.

  • Skin Care Formulations: Enhances texture and spreadability in lotions, sunscreens, and emulsions.

Industrial and Technical Applications

PVP plays a functional role in several industrial processes:

  • Protective Colloid: Stabilises dispersions in paints, coatings, and adhesives.

  • Surface Treatments: Enhances clarity and anti-fog properties in glass and polymer coatings.

Safety Information

Potential Hazards

  • Skin and Eye Irritation: May cause mild irritation; prolonged contact should be avoided.

  • Inhalation: Fine dust particles can lead to temporary respiratory discomfort in confined or poorly ventilated areas.

  • Ingestion: While generally considered non-toxic, ingestion in raw form is not advised.

Safety Precautions

  • Personal Protective Equipment (PPE): Gloves, goggles, and respiratory masks should be worn during handling to prevent irritation.

  • Ventilation: Workspaces should be equipped with adequate ventilation or local exhaust systems.

  • Emergency Response: Rinse eyes or skin with water in case of exposure. Seek medical attention if symptoms persist.

Storage Recommendations

  • Containers: Store in tightly sealed, moisture-proof containers to preserve quality.

  • Conditions: Keep in a cool, dry, and well-ventilated area away from direct heat or light.

Occupational Exposure Controls

  • Engineering Controls: Use of enclosed systems and dust extraction units to minimise airborne exposure.

  • Administrative Controls: Personnel should receive proper training on safe handling practices and potential hazards.

  • Health Surveillance: Monitor staff regularly for signs of allergic or respiratory responses during prolonged exposure.


Environmental Impact and Disposal

PVP is generally safe for the environment under normal industrial usage:

  • Environmental Considerations: Biodegradable under most conditions; does not bioaccumulate or pose long-term ecological risks.

  • Disposal Guidelines: Dispose of in accordance with local waste management regulations. Avoid releasing large volumes into water systems.

PVP’s multifunctional nature, combined with its favourable safety and environmental profile, makes it a valuable ingredient in a wide range of pharmaceutical, cosmetic, and technical applications. Responsible usage and compliance with handling guidelines ensure optimal performance and user safety.